Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TYRP1Tyrosinase related protein 1. (537 aa)    
Predicted Functional Partners:
SLC45A2
Solute carrier family 45 member 2.
   
 
 0.870
DCT
Dopachrome tautomerase.
   
 
  0.869
OCA2
OCA2 melanosomal transmembrane protein.
   
  
 0.866
MITF
Melanocyte inducing transcription factor.
   
 0.858
SLC24A5
Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
 
 0.810
MLANA
Uncharacterized protein.
   
  
 0.802
GPR143
G protein-coupled receptor 143.
   
 
 0.790
GOT1
Aspartate aminotransferase.
    
 0.649
SLC45A1
Solute carrier family 45 member 1.
   
 
 0.648
ASIP
Agouti signaling protein.
      
 0.629
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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