STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM86ATransmembrane protein 86A. (240 aa)    
Predicted Functional Partners:
GET3
ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]
      
 0.543
C11orf54
Chromosome 11 open reading frame 54.
      
 0.541
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif 3.
   
  
 0.527
CX3CL1
C-X3-C motif chemokine ligand 1.
      
 0.523
NXPH2
Neurexophilin; May be signaling molecules that resemble neuropeptides.
      
 0.481
DLST
Dihydrolipoamide S-succinyltransferase.
      
 0.465
G3TR48_LOXAF
TGF_BETA_2 domain-containing protein.
      
 0.463
PPP1R14B
Protein phosphatase 1 regulatory inhibitor subunit 14B.
      
 0.454
MAP2K5
Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.
      
 0.451
LHFPL2
LHFPL tetraspan subfamily member 2.
      
 0.442
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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