STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1991 aa)    
Predicted Functional Partners:
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.989
SCN1B
Sodium voltage-gated channel beta subunit 1.
   
 0.900
SCN2B
Sodium voltage-gated channel beta subunit 2.
   
 0.835
SCN4B
Sodium voltage-gated channel beta subunit 4.
    
 0.819
SCN3B
Sodium voltage-gated channel beta subunit 3.
   
 0.775
GALNT3
Polypeptide N-acetylgalactosaminyltransferase.
 
 
  
 0.736
PDLIM3
PDZ and LIM domain 3.
    
 
 0.723
DIS3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family.
      
 0.720
KCNQ2
Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family.
   
 0.604
WDR35
WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
    
 0.599
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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