Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)    
Predicted Functional Partners:
TNFSF11
Tumor necrosis factor ligand 6B; Belongs to the tumor necrosis factor family.
    
 0.996
ACP5
Tartrate-resistant acid phosphatase type 5.
   
  
 0.727
SOST
Sclerostin.
      
 0.714
BGLAP
Osteocalcin; Binds strongly to apatite and calcium.
      
 0.713
TNFSF14
Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family.
    
 0.698
G3TBU1_LOXAF
Uncharacterized protein.
   
 0.663
NCF2
Neutrophil cytosolic factor 2.
      
 0.596
CD40LG
CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
    
 0.566
SPP1
Secreted phosphoprotein 1.
      
 0.565
PTH
Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.
      
 0.565
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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