| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYP11A1 | FDX1 | ENSLAFP00000007182 | ENSLAFP00000010027 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Uncharacterized protein. | 0.750 |
| CYP11A1 | STAR | ENSLAFP00000007182 | ENSLAFP00000001746 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.674 |
| FDX1 | CYP11A1 | ENSLAFP00000010027 | ENSLAFP00000007182 | Uncharacterized protein. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.750 |
| FDX1 | LOC100654178 | ENSLAFP00000010027 | ENSLAFP00000021300 | Uncharacterized protein. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.750 |
| FDX1 | STAR | ENSLAFP00000010027 | ENSLAFP00000001746 | Uncharacterized protein. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.729 |
| INSL3 | STAR | ENSLAFP00000022371 | ENSLAFP00000001746 | IlGF domain-containing protein. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.671 |
| LOC100654178 | FDX1 | ENSLAFP00000021300 | ENSLAFP00000010027 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Uncharacterized protein. | 0.750 |
| LOC100654178 | STAR | ENSLAFP00000021300 | ENSLAFP00000001746 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.674 |
| STAR | CYP11A1 | ENSLAFP00000001746 | ENSLAFP00000007182 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.674 |
| STAR | FDX1 | ENSLAFP00000001746 | ENSLAFP00000010027 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | Uncharacterized protein. | 0.729 |
| STAR | INSL3 | ENSLAFP00000001746 | ENSLAFP00000022371 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | IlGF domain-containing protein. | 0.671 |
| STAR | LOC100654178 | ENSLAFP00000001746 | ENSLAFP00000021300 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.674 |
| STAR | STARD3 | ENSLAFP00000001746 | ENSLAFP00000027764 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | StAR related lipid transfer domain containing 3. | 0.787 |
| STAR | STARD3NL | ENSLAFP00000001746 | ENSLAFP00000006831 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | STARD3 N-terminal like. | 0.973 |
| STAR | TSPO | ENSLAFP00000001746 | ENSLAFP00000001662 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | Translocator protein. | 0.723 |
| STAR | VDAC1 | ENSLAFP00000001746 | ENSLAFP00000026837 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | Voltage dependent anion channel 1. | 0.962 |
| STAR | VDAC2 | ENSLAFP00000001746 | ENSLAFP00000007989 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | Voltage dependent anion channel 2. | 0.921 |
| STAR | VDAC3 | ENSLAFP00000001746 | ENSLAFP00000011162 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | Voltage dependent anion channel 3. | 0.921 |
| STARD3 | STAR | ENSLAFP00000027764 | ENSLAFP00000001746 | StAR related lipid transfer domain containing 3. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.787 |
| STARD3 | STARD3NL | ENSLAFP00000027764 | ENSLAFP00000006831 | StAR related lipid transfer domain containing 3. | STARD3 N-terminal like. | 0.942 |