Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | CDKN2B | ENSLAFP00000006871 | ENSLAFP00000016776 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cyclin dependent kinase inhibitor 2B. | 0.452 |
| ATM | G3U9C8_LOXAF | ENSLAFP00000006871 | ENSLAFP00000024436 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ubiquitin-like domain-containing protein. | 0.486 |
| ATM | MDM2 | ENSLAFP00000006871 | ENSLAFP00000004935 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.911 |
| ATM | MDM4 | ENSLAFP00000006871 | ENSLAFP00000001814 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.813 |
| ATM | RPS27A | ENSLAFP00000006871 | ENSLAFP00000021261 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ubiquitin-like domain-containing protein. | 0.486 |
| ATM | TP53 | ENSLAFP00000006871 | ENSLAFP00000006292 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.975 |
| CDKN2B | ATM | ENSLAFP00000016776 | ENSLAFP00000006871 | Cyclin dependent kinase inhibitor 2B. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.452 |
| CDKN2B | MDM2 | ENSLAFP00000016776 | ENSLAFP00000004935 | Cyclin dependent kinase inhibitor 2B. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.947 |
| CDKN2B | MDM4 | ENSLAFP00000016776 | ENSLAFP00000001814 | Cyclin dependent kinase inhibitor 2B. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.754 |
| CDKN2B | TP53 | ENSLAFP00000016776 | ENSLAFP00000006292 | Cyclin dependent kinase inhibitor 2B. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.423 |
| G3U9C8_LOXAF | ATM | ENSLAFP00000024436 | ENSLAFP00000006871 | Ubiquitin-like domain-containing protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.486 |
| G3U9C8_LOXAF | MDM2 | ENSLAFP00000024436 | ENSLAFP00000004935 | Ubiquitin-like domain-containing protein. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.879 |
| G3U9C8_LOXAF | MDM4 | ENSLAFP00000024436 | ENSLAFP00000001814 | Ubiquitin-like domain-containing protein. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.748 |
| G3U9C8_LOXAF | RPL11 | ENSLAFP00000024436 | ENSLAFP00000028656 | Ubiquitin-like domain-containing protein. | Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. | 0.984 |
| G3U9C8_LOXAF | TP53 | ENSLAFP00000024436 | ENSLAFP00000006292 | Ubiquitin-like domain-containing protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.479 |
| G3U9C8_LOXAF | UBA52 | ENSLAFP00000024436 | ENSLAFP00000017811 | Ubiquitin-like domain-containing protein. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.987 |
| G3U9C8_LOXAF | USP7 | ENSLAFP00000024436 | ENSLAFP00000006345 | Ubiquitin-like domain-containing protein. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.896 |
| MDM2 | ATM | ENSLAFP00000004935 | ENSLAFP00000006871 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.911 |
| MDM2 | CDKN2B | ENSLAFP00000004935 | ENSLAFP00000016776 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Cyclin dependent kinase inhibitor 2B. | 0.947 |
| MDM2 | G3U9C8_LOXAF | ENSLAFP00000004935 | ENSLAFP00000024436 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Ubiquitin-like domain-containing protein. | 0.879 |
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