HERC6 protein (Loxodonta africana) - STRING interaction network

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HERC6

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. (1035 aa)

Predicted Functional Partners:

ISG15

0.736

TRIP12

0.605

UBE2L6

0.515

UBE2L5

0.482

RCC1

0.460

PSMD4

0.434

RCC1L

0.424

APOB

0.415

ATG7

0.405

RSAD2

0.400

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	HERC6	ENSLAFP00000007741	ENSLAFP00000001926	Apolipoprotein B.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	0.415
APOB	RCC1	ENSLAFP00000007741	ENSLAFP00000025227	Apolipoprotein B.	Regulator of chromosome condensation 1.	0.711
APOB	RCC1L	ENSLAFP00000007741	ENSLAFP00000028029	Apolipoprotein B.	RCC1 like.	0.596
ATG7	HERC6	ENSLAFP00000020951	ENSLAFP00000001926	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	0.405
ATG7	ISG15	ENSLAFP00000020951	ENSLAFP00000015748	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	ISG15 ubiquitin like modifier.	0.520
ATG7	PSMD4	ENSLAFP00000020951	ENSLAFP00000011240	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Proteasome 26S subunit, non-ATPase 4.	0.616
ATG7	TRIP12	ENSLAFP00000020951	ENSLAFP00000014922	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Thyroid hormone receptor interactor 12.	0.960
ATG7	UBE2L5	ENSLAFP00000020951	ENSLAFP00000020202	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.578
ATG7	UBE2L6	ENSLAFP00000020951	ENSLAFP00000010129	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family.	0.578
HERC6	APOB	ENSLAFP00000001926	ENSLAFP00000007741	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	Apolipoprotein B.	0.415
HERC6	ATG7	ENSLAFP00000001926	ENSLAFP00000020951	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.405
HERC6	ISG15	ENSLAFP00000001926	ENSLAFP00000015748	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	ISG15 ubiquitin like modifier.	0.736
HERC6	PSMD4	ENSLAFP00000001926	ENSLAFP00000011240	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	Proteasome 26S subunit, non-ATPase 4.	0.434
HERC6	RCC1	ENSLAFP00000001926	ENSLAFP00000025227	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	Regulator of chromosome condensation 1.	0.460
HERC6	RCC1L	ENSLAFP00000001926	ENSLAFP00000028029	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	RCC1 like.	0.424
HERC6	RSAD2	ENSLAFP00000001926	ENSLAFP00000014333	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	Radical S-adenosyl methionine domain containing 2.	0.400
HERC6	TRIP12	ENSLAFP00000001926	ENSLAFP00000014922	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	Thyroid hormone receptor interactor 12.	0.605
HERC6	UBE2L5	ENSLAFP00000001926	ENSLAFP00000020202	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.482
HERC6	UBE2L6	ENSLAFP00000001926	ENSLAFP00000010129	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family.	0.515
ISG15	ATG7	ENSLAFP00000015748	ENSLAFP00000020951	ISG15 ubiquitin like modifier.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.520

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