NTMT1 protein (Loxodonta africana) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1. (223 aa)

Predicted Functional Partners:

PRMT6

0.638

RCC1

0.574

G3UM63_LOXAF

0.567

METTL27

0.561

METTL17

0.541

KLHL31

0.527

SUOX

0.523

METTL9

0.523

NCBP1

0.497

MRTO4

0.479

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3UM63_LOXAF	MRTO4	ENSLAFP00000028922	ENSLAFP00000018006	Uncharacterized protein.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.653
G3UM63_LOXAF	NTMT1	ENSLAFP00000028922	ENSLAFP00000001959	Uncharacterized protein.	N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.567
G3UM63_LOXAF	PRMT6	ENSLAFP00000028922	ENSLAFP00000018176	Uncharacterized protein.	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.406
G3UM63_LOXAF	SUOX	ENSLAFP00000028922	ENSLAFP00000006911	Uncharacterized protein.	Sulfite oxidase.	0.533
KLHL31	NTMT1	ENSLAFP00000003214	ENSLAFP00000001959	Kelch like family member 31.	N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.527
METTL17	METTL27	ENSLAFP00000005951	ENSLAFP00000029170	Methyltransferase like 17.	Methyltransferase like 27.	0.639
METTL17	METTL9	ENSLAFP00000005951	ENSLAFP00000011977	Methyltransferase like 17.	Methyltransferase like 9.	0.524
METTL17	NTMT1	ENSLAFP00000005951	ENSLAFP00000001959	Methyltransferase like 17.	N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.541
METTL27	METTL17	ENSLAFP00000029170	ENSLAFP00000005951	Methyltransferase like 27.	Methyltransferase like 17.	0.639
METTL27	METTL9	ENSLAFP00000029170	ENSLAFP00000011977	Methyltransferase like 27.	Methyltransferase like 9.	0.523
METTL27	MRTO4	ENSLAFP00000029170	ENSLAFP00000018006	Methyltransferase like 27.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.684
METTL27	NTMT1	ENSLAFP00000029170	ENSLAFP00000001959	Methyltransferase like 27.	N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.561
METTL9	METTL17	ENSLAFP00000011977	ENSLAFP00000005951	Methyltransferase like 9.	Methyltransferase like 17.	0.524
METTL9	METTL27	ENSLAFP00000011977	ENSLAFP00000029170	Methyltransferase like 9.	Methyltransferase like 27.	0.523
METTL9	NTMT1	ENSLAFP00000011977	ENSLAFP00000001959	Methyltransferase like 9.	N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.523
MRTO4	G3UM63_LOXAF	ENSLAFP00000018006	ENSLAFP00000028922	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	Uncharacterized protein.	0.653
MRTO4	METTL27	ENSLAFP00000018006	ENSLAFP00000029170	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	Methyltransferase like 27.	0.684
MRTO4	NTMT1	ENSLAFP00000018006	ENSLAFP00000001959	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.479
MRTO4	PRMT6	ENSLAFP00000018006	ENSLAFP00000018176	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.496
NCBP1	NTMT1	ENSLAFP00000027008	ENSLAFP00000001959	Nuclear cap binding protein subunit 1.	N-terminal Xaa-Pro-Lys N-methyltransferase 1.	0.497

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

8.16e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 15

2.3

5.28

6.31e-12

GO:0046417

Chorismate metabolic process

4 of 6

2.46

3.07

1.32e-06

GO:0009423

Chorismate biosynthetic process

3 of 5

2.41

2.27

5.21e-05

GO:0009095

Aromatic amino acid family biosynthetic process, prephenate pathway

2 of 2

2.63

1.51

0.0017

GO:0008652

Cellular amino acid biosynthetic process

5 of 108

1.3

1.27

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

3 of 6

2.33

1.74

0.00054

GO:0003856

3-dehydroquinate synthase activity

2 of 2

2.63

1.26

0.0051

GO:0016835

Carbon-oxygen lyase activity

4 of 52

1.52

1.2

0.0019

GO:0016829

Lyase activity

5 of 130

1.22

0.99

0.0019

GO:0003824

Catalytic activity

11 of 2283

0.32

0.24

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1157

Aromatic amino acid family biosynthetic process, and Anthranilate synthase component I-like

9 of 19

2.31

7.07

1.22e-16

CL:1159

Chorismate biosynthetic process

4 of 6

2.46

3.31

4.40e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

zga00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 23

2.27

8.0

6.95e-20

zga01230

Biosynthesis of amino acids

10 of 125

1.54

3.22

1.45e-13

zga01110

Biosynthesis of secondary metabolites

11 of 326

1.16

1.77

7.18e-12

zga01100

Metabolic pathways

11 of 716

0.82

0.89

2.77e-08

zga02024

Quorum sensing

2 of 26

1.52

0.69

0.0386

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 1110

0.54

0.36

0.0243

GOCC:0005622

Intracellular

10 of 1523

0.45

0.31

0.0243

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

3 of 11

2.07

1.76

0.00034

KW-0456

Lyase

6 of 116

1.35

1.54

2.15e-05

KW-0170

Cobalt

2 of 4

2.33

1.25

0.0049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00425

Chorismate binding enzyme

2 of 3

2.46

0.82

0.0315

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030963

3-dehydroquinate synthase family

2 of 2

2.63

0.74

0.0466

IPR030960

3-dehydroquinate synthase domain

2 of 2

2.63

0.74

0.0466

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 3

2.46

0.73

0.0466

IPR005801

ADC synthase

2 of 3

2.46

0.73

0.0466

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