STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRAK2Interleukin 1 receptor associated kinase 2. (626 aa)    
Predicted Functional Partners:
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.997
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.996
IRAK4
Interleukin 1 receptor associated kinase 4.
    
 0.986
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.979
TIRAP
TIR domain containing adaptor protein.
   
 0.968
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.945
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    
 0.935
IRAK3
Interleukin 1 receptor associated kinase 3.
    
 0.930
TAB3
TGF-beta activated kinase 1 (MAP3K7) binding protein 3.
    
 0.897
NGFR
Nerve growth factor receptor.
    
  0.877
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.