STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)    
Predicted Functional Partners:
MYCBP2
MYC binding protein 2.
    
 0.898
MAP2K7
Mitogen-activated protein kinase kinase 7.
    
 0.867
MAP3K13
Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
     
  0.762
CASP9
Caspase 9; Belongs to the peptidase C14A family.
     
 0.556
MAPK8IP2
Mitogen-activated protein kinase 8 interacting protein 2.
    
 
 0.430
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
    
 
 0.422
SNX19
Sorting nexin 19.
      
 0.413
FBXO45
F-box protein 45.
    
 
 0.402
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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