FPGS protein (Loxodonta africana) - STRING interaction network

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FPGS

Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (587 aa)

Predicted Functional Partners:

TYMS

0.969

DHFR

0.938

GGH

0.932

MTHFD1L

0.890

MTHFD1

0.890

SHMT1

0.883

SHMT2

0.883

MCF2

0.769

NUDT15

0.765

GCH1

0.731

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHFR	FPGS	ENSLAFP00000028087	ENSLAFP00000002363	DHFR domain-containing protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.938
DHFR	GCH1	ENSLAFP00000028087	ENSLAFP00000002422	DHFR domain-containing protein.	GTP cyclohydrolase 1.	0.494
DHFR	GGH	ENSLAFP00000028087	ENSLAFP00000009644	DHFR domain-containing protein.	Folate gamma-glutamyl hydrolase.	0.904
DHFR	MTHFD1	ENSLAFP00000028087	ENSLAFP00000018131	DHFR domain-containing protein.	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.	0.884
DHFR	MTHFD1L	ENSLAFP00000028087	ENSLAFP00000001363	DHFR domain-containing protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.884
DHFR	SHMT1	ENSLAFP00000028087	ENSLAFP00000007740	DHFR domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.918
DHFR	SHMT2	ENSLAFP00000028087	ENSLAFP00000009635	DHFR domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.918
DHFR	TYMS	ENSLAFP00000028087	ENSLAFP00000012486	DHFR domain-containing protein.	Thymidylate synthetase.	0.996
FPGS	DHFR	ENSLAFP00000002363	ENSLAFP00000028087	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	DHFR domain-containing protein.	0.938
FPGS	GCH1	ENSLAFP00000002363	ENSLAFP00000002422	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	GTP cyclohydrolase 1.	0.731
FPGS	GGH	ENSLAFP00000002363	ENSLAFP00000009644	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Folate gamma-glutamyl hydrolase.	0.932
FPGS	MCF2	ENSLAFP00000002363	ENSLAFP00000014213	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	MCF.2 cell line derived transforming sequence.	0.769
FPGS	MTHFD1	ENSLAFP00000002363	ENSLAFP00000018131	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.	0.890
FPGS	MTHFD1L	ENSLAFP00000002363	ENSLAFP00000001363	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.890
FPGS	NUDT15	ENSLAFP00000002363	ENSLAFP00000014459	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Nudix hydrolase 15; Belongs to the Nudix hydrolase family.	0.765
FPGS	SHMT1	ENSLAFP00000002363	ENSLAFP00000007740	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.883
FPGS	SHMT2	ENSLAFP00000002363	ENSLAFP00000009635	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.883
FPGS	TYMS	ENSLAFP00000002363	ENSLAFP00000012486	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Thymidylate synthetase.	0.969
GCH1	DHFR	ENSLAFP00000002422	ENSLAFP00000028087	GTP cyclohydrolase 1.	DHFR domain-containing protein.	0.494
GCH1	FPGS	ENSLAFP00000002422	ENSLAFP00000002363	GTP cyclohydrolase 1.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.731

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