| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHFR | FPGS | ENSLAFP00000028087 | ENSLAFP00000002363 | DHFR domain-containing protein. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.994 |
| DHFR | GGH | ENSLAFP00000028087 | ENSLAFP00000009644 | DHFR domain-containing protein. | Folate gamma-glutamyl hydrolase. | 0.928 |
| DHFR | MTHFD1 | ENSLAFP00000028087 | ENSLAFP00000018131 | DHFR domain-containing protein. | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. | 0.963 |
| DHFR | MTHFD1L | ENSLAFP00000028087 | ENSLAFP00000001363 | DHFR domain-containing protein. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.963 |
| DHFR | MTHFD2 | ENSLAFP00000028087 | ENSLAFP00000012014 | DHFR domain-containing protein. | Uncharacterized protein. | 0.604 |
| DHFR | MTHFD2L | ENSLAFP00000028087 | ENSLAFP00000006595 | DHFR domain-containing protein. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. | 0.604 |
| DHFR | NUDT15 | ENSLAFP00000028087 | ENSLAFP00000014459 | DHFR domain-containing protein. | Nudix hydrolase 15; Belongs to the Nudix hydrolase family. | 0.436 |
| DHFR | SHMT1 | ENSLAFP00000028087 | ENSLAFP00000007740 | DHFR domain-containing protein. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.990 |
| DHFR | SHMT2 | ENSLAFP00000028087 | ENSLAFP00000009635 | DHFR domain-containing protein. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.990 |
| DHFR | TYMS | ENSLAFP00000028087 | ENSLAFP00000012486 | DHFR domain-containing protein. | Thymidylate synthetase. | 0.999 |
| FPGS | DHFR | ENSLAFP00000002363 | ENSLAFP00000028087 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | DHFR domain-containing protein. | 0.994 |
| FPGS | GGH | ENSLAFP00000002363 | ENSLAFP00000009644 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Folate gamma-glutamyl hydrolase. | 0.943 |
| FPGS | MTHFD1 | ENSLAFP00000002363 | ENSLAFP00000018131 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. | 0.914 |
| FPGS | MTHFD1L | ENSLAFP00000002363 | ENSLAFP00000001363 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.914 |
| FPGS | MTHFD2 | ENSLAFP00000002363 | ENSLAFP00000012014 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Uncharacterized protein. | 0.907 |
| FPGS | MTHFD2L | ENSLAFP00000002363 | ENSLAFP00000006595 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. | 0.907 |
| FPGS | NUDT15 | ENSLAFP00000002363 | ENSLAFP00000014459 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Nudix hydrolase 15; Belongs to the Nudix hydrolase family. | 0.920 |
| FPGS | SHMT1 | ENSLAFP00000002363 | ENSLAFP00000007740 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.915 |
| FPGS | SHMT2 | ENSLAFP00000002363 | ENSLAFP00000009635 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.915 |
| FPGS | TYMS | ENSLAFP00000002363 | ENSLAFP00000012486 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthetase. | 0.994 |