Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TTC33Tetratricopeptide repeat domain 33. (262 aa)    
Predicted Functional Partners:
WDR61
WD repeat domain 61.
    
 0.821
PHF5A
PHD finger protein 5A.
    
   0.804
CCDC97
Coiled-coil domain containing 97.
    
   0.804
TCL1A
T cell leukemia/lymphoma 1A.
    
   0.783
SF3B6
Splicing factor 3b subunit 6.
    
   0.767
GET3
ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]
   
 0.719
SF3B2
Splicing factor 3b subunit 2.
    
   0.672
SF3B5
Splicing factor 3B subunit 5; Belongs to the SF3B5 family.
   
   0.667
ZRSR2
Uncharacterized protein.
    
   0.665
GET4
Guided entry of tail-anchored proteins factor 4.
   
 0.665
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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