node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG7 | HECTD2 | ENSLAFP00000020951 | ENSLAFP00000002634 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | HECT domain E3 ubiquitin protein ligase 2. | 0.405 |
ATG7 | ISG15 | ENSLAFP00000020951 | ENSLAFP00000015748 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | ISG15 ubiquitin like modifier. | 0.520 |
ATG7 | PSMD4 | ENSLAFP00000020951 | ENSLAFP00000011240 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | Proteasome 26S subunit, non-ATPase 4. | 0.616 |
ATG7 | TRIP12 | ENSLAFP00000020951 | ENSLAFP00000014922 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | Thyroid hormone receptor interactor 12. | 0.960 |
ATG7 | UBE2L5 | ENSLAFP00000020951 | ENSLAFP00000020202 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.578 |
ATG7 | UBE2L6 | ENSLAFP00000020951 | ENSLAFP00000010129 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. | 0.578 |
HECTD2 | ATG7 | ENSLAFP00000002634 | ENSLAFP00000020951 | HECT domain E3 ubiquitin protein ligase 2. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | 0.405 |
HECTD2 | ISG15 | ENSLAFP00000002634 | ENSLAFP00000015748 | HECT domain E3 ubiquitin protein ligase 2. | ISG15 ubiquitin like modifier. | 0.492 |
HECTD2 | NOC3L | ENSLAFP00000002634 | ENSLAFP00000001433 | HECT domain E3 ubiquitin protein ligase 2. | Nucleolar complex protein 3 homolog. | 0.457 |
HECTD2 | PCGF5 | ENSLAFP00000002634 | ENSLAFP00000009335 | HECT domain E3 ubiquitin protein ligase 2. | Polycomb group ring finger 5. | 0.447 |
HECTD2 | PSMD4 | ENSLAFP00000002634 | ENSLAFP00000011240 | HECT domain E3 ubiquitin protein ligase 2. | Proteasome 26S subunit, non-ATPase 4. | 0.434 |
HECTD2 | TRIP12 | ENSLAFP00000002634 | ENSLAFP00000014922 | HECT domain E3 ubiquitin protein ligase 2. | Thyroid hormone receptor interactor 12. | 0.605 |
HECTD2 | UBE2L5 | ENSLAFP00000002634 | ENSLAFP00000020202 | HECT domain E3 ubiquitin protein ligase 2. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.482 |
HECTD2 | UBE2L6 | ENSLAFP00000002634 | ENSLAFP00000010129 | HECT domain E3 ubiquitin protein ligase 2. | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. | 0.482 |
ISG15 | ATG7 | ENSLAFP00000015748 | ENSLAFP00000020951 | ISG15 ubiquitin like modifier. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | 0.520 |
ISG15 | HECTD2 | ENSLAFP00000015748 | ENSLAFP00000002634 | ISG15 ubiquitin like modifier. | HECT domain E3 ubiquitin protein ligase 2. | 0.492 |
ISG15 | PSMD4 | ENSLAFP00000015748 | ENSLAFP00000011240 | ISG15 ubiquitin like modifier. | Proteasome 26S subunit, non-ATPase 4. | 0.737 |
ISG15 | TRIP12 | ENSLAFP00000015748 | ENSLAFP00000014922 | ISG15 ubiquitin like modifier. | Thyroid hormone receptor interactor 12. | 0.890 |
ISG15 | UBE2L5 | ENSLAFP00000015748 | ENSLAFP00000020202 | ISG15 ubiquitin like modifier. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.785 |
ISG15 | UBE2L6 | ENSLAFP00000015748 | ENSLAFP00000010129 | ISG15 ubiquitin like modifier. | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. | 0.893 |