DENND2C protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

DENND2C

DENN domain containing 2C. (919 aa)

Predicted Functional Partners:

C3orf67

0.763

RAB9B

0.667

RAB9A

0.667

RHOBTB3

0.666

AVL9

0.546

IFT27

0.528

RAB35

0.528

SYTL1

0.497

CHM

0.425

TPCN2

0.418

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AVL9	DENND2C	ENSLAFP00000008817	ENSLAFP00000002644	AVL9 cell migration associated.	DENN domain containing 2C.	0.546
AVL9	RAB35	ENSLAFP00000008817	ENSLAFP00000010128	AVL9 cell migration associated.	RAB35, member RAS oncogene family.	0.529
C3orf67	DENND2C	ENSLAFP00000008242	ENSLAFP00000002644	Chromosome 3 open reading frame 67.	DENN domain containing 2C.	0.763
CHM	DENND2C	ENSLAFP00000000437	ENSLAFP00000002644	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	DENN domain containing 2C.	0.425
CHM	IFT27	ENSLAFP00000000437	ENSLAFP00000004495	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Intraflagellar transport 27.	0.516
CHM	RAB35	ENSLAFP00000000437	ENSLAFP00000010128	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB35, member RAS oncogene family.	0.885
CHM	RAB9A	ENSLAFP00000000437	ENSLAFP00000026334	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB9A, member RAS oncogene family.	0.732
CHM	RAB9B	ENSLAFP00000000437	ENSLAFP00000017478	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB9B, member RAS oncogene family.	0.732
DENND2C	AVL9	ENSLAFP00000002644	ENSLAFP00000008817	DENN domain containing 2C.	AVL9 cell migration associated.	0.546
DENND2C	C3orf67	ENSLAFP00000002644	ENSLAFP00000008242	DENN domain containing 2C.	Chromosome 3 open reading frame 67.	0.763
DENND2C	CHM	ENSLAFP00000002644	ENSLAFP00000000437	DENN domain containing 2C.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.425
DENND2C	IFT27	ENSLAFP00000002644	ENSLAFP00000004495	DENN domain containing 2C.	Intraflagellar transport 27.	0.528
DENND2C	RAB35	ENSLAFP00000002644	ENSLAFP00000010128	DENN domain containing 2C.	RAB35, member RAS oncogene family.	0.528
DENND2C	RAB9A	ENSLAFP00000002644	ENSLAFP00000026334	DENN domain containing 2C.	RAB9A, member RAS oncogene family.	0.667
DENND2C	RAB9B	ENSLAFP00000002644	ENSLAFP00000017478	DENN domain containing 2C.	RAB9B, member RAS oncogene family.	0.667
DENND2C	RHOBTB3	ENSLAFP00000002644	ENSLAFP00000023057	DENN domain containing 2C.	Rho related BTB domain containing 3.	0.666
DENND2C	SYTL1	ENSLAFP00000002644	ENSLAFP00000027890	DENN domain containing 2C.	Synaptotagmin like 1.	0.497
DENND2C	TPCN2	ENSLAFP00000002644	ENSLAFP00000006693	DENN domain containing 2C.	Ion_trans domain-containing protein.	0.418
IFT27	CHM	ENSLAFP00000004495	ENSLAFP00000000437	Intraflagellar transport 27.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.516
IFT27	DENND2C	ENSLAFP00000004495	ENSLAFP00000002644	Intraflagellar transport 27.	DENN domain containing 2C.	0.528

page 1 of 2

Server load: low (16%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About