Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SKA2Spindle and kinetochore associated complex subunit 2. (109 aa)    
Predicted Functional Partners:
SKA1
Spindle and kinetochore associated complex subunit 1.
    
 0.996
SKA3
Spindle and kinetochore associated complex subunit 3.
   
 0.989
PLK1
Serine/threonine-protein kinase PLK.
   
 
 0.956
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
     
 0.949
SGO1
Shugoshin 1.
   
 
 0.942
CENPF
Centromere protein F.
   
 
 0.928
NUDC
Nuclear distribution C, dynein complex regulator.
     
 0.919
SGO2
Shugoshin 2.
   
 
  0.913
PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]
     
  0.908
XPO1
Exportin 1.
     
  0.908
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.