FURIN protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

FURIN

Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (792 aa)

Predicted Functional Partners:

MMP11

0.937

F2

0.936

G3TJV3_LOXAF

0.924

PDGFB

0.921

PROS1

0.917

NOTCH1

0.902

MMP14

0.900

TGFB1

0.896

BGLAP

0.891

F10

0.875

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BGLAP	FURIN	ENSLAFP00000014103	ENSLAFP00000002835	Osteocalcin; Binds strongly to apatite and calcium.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.891
BGLAP	TGFB1	ENSLAFP00000014103	ENSLAFP00000006447	Osteocalcin; Binds strongly to apatite and calcium.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.508
F10	F2	ENSLAFP00000020209	ENSLAFP00000008694	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.987
F10	FURIN	ENSLAFP00000020209	ENSLAFP00000002835	Coagulation factor X.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.875
F10	G3TJV3_LOXAF	ENSLAFP00000020209	ENSLAFP00000015042	Coagulation factor X.	Uncharacterized protein.	0.538
F2	F10	ENSLAFP00000008694	ENSLAFP00000020209	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.987
F2	FURIN	ENSLAFP00000008694	ENSLAFP00000002835	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.936
F2	G3TJV3_LOXAF	ENSLAFP00000008694	ENSLAFP00000015042	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.985
F2	PROS1	ENSLAFP00000008694	ENSLAFP00000010470	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein S.	0.549
FURIN	BGLAP	ENSLAFP00000002835	ENSLAFP00000014103	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Osteocalcin; Binds strongly to apatite and calcium.	0.891
FURIN	F10	ENSLAFP00000002835	ENSLAFP00000020209	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Coagulation factor X.	0.875
FURIN	F2	ENSLAFP00000002835	ENSLAFP00000008694	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.936
FURIN	G3TJV3_LOXAF	ENSLAFP00000002835	ENSLAFP00000015042	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Uncharacterized protein.	0.924
FURIN	MMP11	ENSLAFP00000002835	ENSLAFP00000005754	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Matrix metallopeptidase 11.	0.937
FURIN	MMP14	ENSLAFP00000002835	ENSLAFP00000001852	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Matrix metallopeptidase 14.	0.900
FURIN	NOTCH1	ENSLAFP00000002835	ENSLAFP00000017804	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Uncharacterized protein.	0.902
FURIN	PDGFB	ENSLAFP00000002835	ENSLAFP00000006549	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.921
FURIN	PROS1	ENSLAFP00000002835	ENSLAFP00000010470	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Protein S.	0.917
FURIN	TGFB1	ENSLAFP00000002835	ENSLAFP00000006447	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.896
G3TJV3_LOXAF	F10	ENSLAFP00000015042	ENSLAFP00000020209	Uncharacterized protein.	Coagulation factor X.	0.538

page 1 of 2

Server load: low (12%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About