SYP protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

SYP

Synaptophysin. (221 aa)

Predicted Functional Partners:

SNAP25

0.779

VAMP1

0.774

NAGK

0.764

GNE

0.726

SLC17A8

0.605

PHF1

0.602

MAG

0.597

BDNF

0.597

TH

0.580

DCX

0.579

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	DCX	ENSLAFP00000029378	ENSLAFP00000004685	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Doublecortin.	0.622
BDNF	MAG	ENSLAFP00000029378	ENSLAFP00000013660	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Myelin associated glycoprotein.	0.404
BDNF	SNAP25	ENSLAFP00000029378	ENSLAFP00000011551	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.473
BDNF	SYP	ENSLAFP00000029378	ENSLAFP00000002911	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Synaptophysin.	0.597
BDNF	TH	ENSLAFP00000029378	ENSLAFP00000021655	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine hydroxylase.	0.814
DCX	BDNF	ENSLAFP00000004685	ENSLAFP00000029378	Doublecortin.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.622
DCX	PHF1	ENSLAFP00000004685	ENSLAFP00000004923	Doublecortin.	PHD finger protein 1.	0.737
DCX	SYP	ENSLAFP00000004685	ENSLAFP00000002911	Doublecortin.	Synaptophysin.	0.579
DCX	TH	ENSLAFP00000004685	ENSLAFP00000021655	Doublecortin.	Tyrosine hydroxylase.	0.884
GNE	SYP	ENSLAFP00000014809	ENSLAFP00000002911	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	Synaptophysin.	0.726
MAG	BDNF	ENSLAFP00000013660	ENSLAFP00000029378	Myelin associated glycoprotein.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.404
MAG	SYP	ENSLAFP00000013660	ENSLAFP00000002911	Myelin associated glycoprotein.	Synaptophysin.	0.597
NAGK	SYP	ENSLAFP00000010657	ENSLAFP00000002911	N-acetylglucosamine kinase.	Synaptophysin.	0.764
PHF1	DCX	ENSLAFP00000004923	ENSLAFP00000004685	PHD finger protein 1.	Doublecortin.	0.737
PHF1	SYP	ENSLAFP00000004923	ENSLAFP00000002911	PHD finger protein 1.	Synaptophysin.	0.602
PHF1	TH	ENSLAFP00000004923	ENSLAFP00000021655	PHD finger protein 1.	Tyrosine hydroxylase.	0.499
SLC17A8	SNAP25	ENSLAFP00000009495	ENSLAFP00000011551	Solute carrier family 17 member 8.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.490
SLC17A8	SYP	ENSLAFP00000009495	ENSLAFP00000002911	Solute carrier family 17 member 8.	Synaptophysin.	0.605
SLC17A8	VAMP1	ENSLAFP00000009495	ENSLAFP00000001759	Solute carrier family 17 member 8.	Vesicle associated membrane protein 1.	0.674
SNAP25	BDNF	ENSLAFP00000011551	ENSLAFP00000029378	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.473

page 1 of 2

Server load: low (16%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About