ABCD2 protein (Loxodonta africana) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ABCD2

ATP binding cassette subfamily D member 2. (742 aa)

Predicted Functional Partners:

PEX19

0.781

ABCD3

0.723

PEX13

0.718

PEX3

0.709

SCP2

0.694

PEX14

0.652

PEX12

0.642

SLC25A17

0.632

ABCD4

0.615

PEX16

0.605

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD2	ABCD3	ENSLAFP00000002925	ENSLAFP00000003109	ATP binding cassette subfamily D member 2.	ATP binding cassette subfamily D member 3.	0.723
ABCD2	ABCD4	ENSLAFP00000002925	ENSLAFP00000002397	ATP binding cassette subfamily D member 2.	ATP binding cassette subfamily D member 4.	0.615
ABCD2	PEX12	ENSLAFP00000002925	ENSLAFP00000009891	ATP binding cassette subfamily D member 2.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.642
ABCD2	PEX13	ENSLAFP00000002925	ENSLAFP00000000691	ATP binding cassette subfamily D member 2.	Peroxisomal biogenesis factor 13.	0.718
ABCD2	PEX14	ENSLAFP00000002925	ENSLAFP00000024736	ATP binding cassette subfamily D member 2.	Peroxisomal biogenesis factor 14.	0.652
ABCD2	PEX16	ENSLAFP00000002925	ENSLAFP00000025749	ATP binding cassette subfamily D member 2.	Peroxisomal membrane protein PEX16.	0.605
ABCD2	PEX19	ENSLAFP00000002925	ENSLAFP00000025557	ATP binding cassette subfamily D member 2.	Uncharacterized protein.	0.781
ABCD2	PEX3	ENSLAFP00000002925	ENSLAFP00000010536	ATP binding cassette subfamily D member 2.	Peroxisomal biogenesis factor 3.	0.709
ABCD2	SCP2	ENSLAFP00000002925	ENSLAFP00000003587	ATP binding cassette subfamily D member 2.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.694
ABCD2	SLC25A17	ENSLAFP00000002925	ENSLAFP00000009607	ATP binding cassette subfamily D member 2.	Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.632
ABCD3	ABCD2	ENSLAFP00000003109	ENSLAFP00000002925	ATP binding cassette subfamily D member 3.	ATP binding cassette subfamily D member 2.	0.723
ABCD3	PEX12	ENSLAFP00000003109	ENSLAFP00000009891	ATP binding cassette subfamily D member 3.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.800
ABCD3	PEX13	ENSLAFP00000003109	ENSLAFP00000000691	ATP binding cassette subfamily D member 3.	Peroxisomal biogenesis factor 13.	0.831
ABCD3	PEX14	ENSLAFP00000003109	ENSLAFP00000024736	ATP binding cassette subfamily D member 3.	Peroxisomal biogenesis factor 14.	0.750
ABCD3	PEX16	ENSLAFP00000003109	ENSLAFP00000025749	ATP binding cassette subfamily D member 3.	Peroxisomal membrane protein PEX16.	0.831
ABCD3	PEX19	ENSLAFP00000003109	ENSLAFP00000025557	ATP binding cassette subfamily D member 3.	Uncharacterized protein.	0.923
ABCD3	PEX3	ENSLAFP00000003109	ENSLAFP00000010536	ATP binding cassette subfamily D member 3.	Peroxisomal biogenesis factor 3.	0.860
ABCD3	SCP2	ENSLAFP00000003109	ENSLAFP00000003587	ATP binding cassette subfamily D member 3.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.648
ABCD3	SLC25A17	ENSLAFP00000003109	ENSLAFP00000009607	ATP binding cassette subfamily D member 3.	Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.753
ABCD4	ABCD2	ENSLAFP00000002397	ENSLAFP00000002925	ATP binding cassette subfamily D member 4.	ATP binding cassette subfamily D member 2.	0.615

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.803

expected number of edges:

14

PPI enrichment p-value:

1.95e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007601

Visual perception

5 of 105

1.9

2.16

2.51e-05

GO:0051606

Detection of stimulus

5 of 202

1.62

1.69

0.00010

GO:0007602

Phototransduction

3 of 28

2.25

1.69

0.00063

GO:0007603

Phototransduction, visible light

2 of 4

2.92

1.39

0.0030

GO:0001580

Detection of chemical stimulus involved in sensory perception of bitter taste

2 of 5

2.82

1.33

0.0039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004703

G protein-coupled receptor kinase activity

3 of 8

2.8

2.28

6.64e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 34

2.39

3.91

1.89e-08

GO:0001750

Photoreceptor outer segment

4 of 49

2.13

2.69

3.57e-06

GO:0001917

Photoreceptor inner segment

3 of 36

2.14

1.97

0.00014

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25806532

(2015) Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation.

5 of 7

3.08

5.85

1.60e-11

PMID:29321241

(2018) Evolution of the shut-off steps of vertebrate phototransduction.

3 of 5

3.0

3.41e-06

PMID:27296292

(2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity.

3 of 7

2.85

2.89

4.87e-06

PMID:35412676

(2022) Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction.

3 of 11

2.66

2.67

1.11e-05

PMID:30257895

(2018) Evolution of the calcium feedback steps of vertebrate phototransduction.

3 of 11

2.66

2.67

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27653

Rhodopsin, and GPCR kinase

6 of 11

2.96

6.77

2.08e-13

CL:27402

Mixed, incl. Amine ligand-binding receptors, and GTPase complex

11 of 172

2.03

6.6

2.76e-19

CL:27656

Methylation, and Vision

4 of 5

3.13

4.58

4.24e-09

CL:27492

Sensory perception of bitter taste, and Retinal cGMP phosphodiesterase, gamma subunit

4 of 5

3.13

4.58

4.24e-09

CL:27427

GTPase complex, and Prostanoid receptor

5 of 39

2.33

3.96

1.11e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04744

Phototransduction

10 of 39

2.63

10.84

1.47e-23

map04371

Apelin signaling pathway

3 of 144

1.54

0.98

0.0077

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2514856

The phototransduction cascade

9 of 42

2.55

8.78

4.24e-19

MAP-2514859

Inactivation, recovery and regulation of the phototransduction cascade

8 of 41

2.51

7.57

1.92e-16

MAP-2187338

Visual phototransduction

9 of 118

2.1

6.06

8.18e-16

MAP-9709957

Sensory Perception

10 of 264

1.8

4.65

2.10e-15

MAP-2485179

Activation of the phototransduction cascade

4 of 16

2.62

3.68

1.11e-07

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 10491

0.24

0.23

0.0194

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0001917

Photoreceptor inner segment

4 of 22

2.48

3.05

1.55e-06

GOCC:0005834

Heterotrimeric G-protein complex

3 of 10

2.7

2.42

3.41e-05

GOCC:0001750

Photoreceptor outer segment

2 of 38

1.94

0.76

0.0376

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0488

Methylation

2 of 2

3.22

1.77

0.00064

KW-0723

Serine/threonine-protein kinase

3 of 194

1.41

0.73

0.0270

KW-0807

Transducer

4 of 569

1.07

0.61

0.0270

KW-0547

Nucleotide-binding

5 of 993

0.92

0.54

0.0270

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000239

GPCR kinase

3 of 8

2.8

2.06

0.00017

IPR044926

RGS, subdomain 2

3 of 38

2.12

1.21

0.0052

IPR036305

RGS domain superfamily

3 of 38

2.12

1.21

0.0052

IPR016137

RGS domain

3 of 37

2.13

1.21

0.0052

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 5

2.82

1.17

0.0075

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00315

Regulator of G protein signalling domain

3 of 32

2.19

1.63

0.00078

SM00133

Extension to Ser/Thr-type protein kinases

3 of 54

1.97

1.41

0.0017

SM00275

G protein alpha subunit

2 of 15

2.35

1.06

0.0111

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