Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (96 aa)    
Predicted Functional Partners:
GNRH2
Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.
     
 0.980
GNRHR
Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.
     
 0.935
G3T6Q5_LOXAF
G_PROTEIN_RECEP_F1_2 domain-containing protein.
     
 0.909
G3U0D9_LOXAF
G_PROTEIN_RECEP_F1_2 domain-containing protein.
     
 0.819
MAPK1
Mitogen-activated protein kinase.
     
 0.804
MAPK3
Mitogen-activated protein kinase.
     
 0.804
AKT2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.770
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.770
AKT1
Non-specific serine/threonine protein kinase.
     
 0.770
TRH
Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
     
 0.732
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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