LEPR protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LEPR

Leptin receptor. (835 aa)

Predicted Functional Partners:

JAK2

0.994

LEP

0.988

SOCS3

0.967

JAK3

0.914

JAK1

0.866

PRL

0.860

IL6

0.769

ADIPOQ

0.725

CNTF

0.724

EGF

0.701

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	IL6	ENSLAFP00000003027	ENSLAFP00000013050	Adiponectin, C1Q and collagen domain containing.	Interleukin 6.	0.653
ADIPOQ	LEP	ENSLAFP00000003027	ENSLAFP00000008966	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.903
ADIPOQ	LEPR	ENSLAFP00000003027	ENSLAFP00000003001	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.725
CNTF	IL6	ENSLAFP00000028639	ENSLAFP00000013050	Ciliary neurotrophic factor.	Interleukin 6.	0.543
CNTF	JAK1	ENSLAFP00000028639	ENSLAFP00000021176	Ciliary neurotrophic factor.	Tyrosine-protein kinase.	0.469
CNTF	JAK2	ENSLAFP00000028639	ENSLAFP00000006285	Ciliary neurotrophic factor.	Tyrosine-protein kinase.	0.411
CNTF	JAK3	ENSLAFP00000028639	ENSLAFP00000012874	Ciliary neurotrophic factor.	Tyrosine-protein kinase.	0.411
CNTF	LEP	ENSLAFP00000028639	ENSLAFP00000008966	Ciliary neurotrophic factor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.925
CNTF	LEPR	ENSLAFP00000028639	ENSLAFP00000003001	Ciliary neurotrophic factor.	Leptin receptor.	0.724
CNTF	PRL	ENSLAFP00000028639	ENSLAFP00000016822	Ciliary neurotrophic factor.	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.	0.921
EGF	IL6	ENSLAFP00000011563	ENSLAFP00000013050	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Interleukin 6.	0.565
EGF	LEPR	ENSLAFP00000011563	ENSLAFP00000003001	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Leptin receptor.	0.701
IL6	ADIPOQ	ENSLAFP00000013050	ENSLAFP00000003027	Interleukin 6.	Adiponectin, C1Q and collagen domain containing.	0.653
IL6	CNTF	ENSLAFP00000013050	ENSLAFP00000028639	Interleukin 6.	Ciliary neurotrophic factor.	0.543
IL6	EGF	ENSLAFP00000013050	ENSLAFP00000011563	Interleukin 6.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.565
IL6	JAK1	ENSLAFP00000013050	ENSLAFP00000021176	Interleukin 6.	Tyrosine-protein kinase.	0.980
IL6	JAK2	ENSLAFP00000013050	ENSLAFP00000006285	Interleukin 6.	Tyrosine-protein kinase.	0.979
IL6	JAK3	ENSLAFP00000013050	ENSLAFP00000012874	Interleukin 6.	Tyrosine-protein kinase.	0.852
IL6	LEP	ENSLAFP00000013050	ENSLAFP00000008966	Interleukin 6.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.676
IL6	LEPR	ENSLAFP00000013050	ENSLAFP00000003001	Interleukin 6.	Leptin receptor.	0.769

page 1 of 4

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About