Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HGDHomogentisate 1,2-dioxygenase. (445 aa)    
Predicted Functional Partners:
HPD
4-hydroxyphenylpyruvate dioxygenase.
  
 0.993
HPDL
4-hydroxyphenylpyruvate dioxygenase.
 
 0.981
GSTZ1
Glutathione S-transferase zeta 1; Belongs to the GST superfamily.
 
 
 0.973
FAH
Fumarylacetoacetase.
 
 0.911
F13B
Coagulation factor XIII B chain.
   
  
 0.833
AGXT2
Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.778
PAH
Phenylalanine hydroxylase.
  
  
 0.778
TAT
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
   
  
 0.728
FAHD1
Fumarylacetoacetate hydrolase domain containing 1.
  
 
 0.664
FAHD2A
Fumarylacetoacetate hydrolase domain containing 2A.
  
 
 0.664
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.