STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PASKPAS domain containing serine/threonine kinase. (1331 aa)    
Predicted Functional Partners:
UGP2
UTP--glucose-1-phosphate uridylyltransferase.
   
 0.776
PPP1R7
Protein phosphatase 1 regulatory subunit 7.
    
 0.747
UCK2
Uridine-cytidine kinase 2.
   
 0.694
PTPRZ1
Protein tyrosine phosphatase receptor type Z1.
    
 0.672
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
  0.601
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
  
 0.597
SLC12A9
Solute carrier family 12 member 9.
    
 0.586
DSG2
Desmoglein 2.
    
 0.582
FUT1
L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family.
    
 0.580
LAT2
Linker for activation of T cells family member 2.
    
 0.573
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.