STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SQLESqualene epoxidase. (569 aa)    
Predicted Functional Partners:
LSS
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
  
 
 0.998
FDFT1
Farnesyl-diphosphate farnesyltransferase 1.
  
 
 0.997
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
  
 0.987
SIGMAR1
Sigma non-opioid intracellular receptor 1.
   
 
 0.975
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.961
NSDHL
NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.
   
 
 0.947
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
  
 0.944
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 
 0.911
LOC100673402
Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.
   
 
 0.911
FAXDC2
Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family.
   
 
 0.911
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.