Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ANKLE2Ankyrin repeat and LEM domain containing 2. (930 aa)    
Predicted Functional Partners:
VRK1
VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily.
   
 0.980
VRK2
VRK serine/threonine kinase 2.
   
 0.975
SIRT2
NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.
    
 0.866
PPP2R1A
Protein phosphatase 2 scaffold subunit Aalpha.
    
  0.835
PPP2R1B
Protein phosphatase 2 scaffold subunit Abeta.
    
  0.835
BANF1
Barrier to autointegration factor 1.
    
 0.831
RHOG
Ras homolog family member G.
    
  0.797
PPP2CA
Serine/threonine-protein phosphatase.
    
 0.712
G3TWH0_LOXAF
Serine/threonine-protein phosphatase.
    
 0.712
G3U6P2_LOXAF
Metallophos domain-containing protein.
    
 0.712
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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