Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (502 aa)    
Predicted Functional Partners:
APP
Amyloid beta precursor protein.
    
 0.993
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.952
RTN3
Reticulon.
    
 0.941
RTN4
Reticulon.
    
 0.931
BACE2
Beta-secretase 2; Belongs to the peptidase A1 family.
     
  0.870
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 
 0.823
GGA3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3.
    
 0.789
APLP2
Amyloid beta precursor like protein 2.
    
 0.745
APLP1
Amyloid beta precursor like protein 1.
    
 0.714
ADAM10
ADAM metallopeptidase domain 10.
    
 
 0.691
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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