STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (502 aa)    
Predicted Functional Partners:
RTN4
Reticulon.
   
 0.962
RTN3
Reticulon.
   
 0.956
APP
Amyloid beta precursor protein.
    
 0.940
BACE2
Beta-secretase 2; Belongs to the peptidase A1 family.
  
  
 
0.902
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.870
RTN2
Reticulon.
   
 
 0.709
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 
 0.674
IDE
Insulin degrading enzyme; Belongs to the peptidase M16 family.
     
 0.615
APLP1
Amyloid beta precursor like protein 1.
    
 0.613
APLP2
Amyloid beta precursor like protein 2.
    
 0.597
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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