STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TYK2Tyrosine-protein kinase. (1169 aa)    
Predicted Functional Partners:
IFNAR1
Interferon alpha and beta receptor subunit 1.
   
 0.997
IL12RB1
Interleukin 12 receptor subunit beta 1.
   
 0.987
IFNAR2
Uncharacterized protein.
   
 0.985
STAT2
Signal transducer and activator of transcription.
   
 0.985
STAT3
Signal transducer and activator of transcription.
   
 0.982
STAT1
Signal transducer and activator of transcription.
   
 0.981
IRF9
Interferon regulatory factor 9.
    
 0.978
SOCS1
Suppressor of cytokine signaling 1.
    
 0.972
STAT4
Signal transducer and activator of transcription.
   
 0.968
IL10RB
Interleukin 10 receptor subunit beta.
   
 0.967
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.