| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | ATR | ENSLAFP00000006871 | ENSLAFP00000012949 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.987 |
| ATM | BRCA2 | ENSLAFP00000006871 | ENSLAFP00000002234 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA2 DNA repair associated. | 0.982 |
| ATM | E2F1 | ENSLAFP00000006871 | ENSLAFP00000015179 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E2F transcription factor 1. | 0.653 |
| ATM | MCPH1 | ENSLAFP00000006871 | ENSLAFP00000003288 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCT domain-containing protein. | 0.805 |
| ATM | RAD51 | ENSLAFP00000006871 | ENSLAFP00000007349 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.983 |
| ATM | WRN | ENSLAFP00000006871 | ENSLAFP00000003703 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | WRN RecQ like helicase. | 0.982 |
| ATR | ATM | ENSLAFP00000012949 | ENSLAFP00000006871 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.987 |
| ATR | BRCA2 | ENSLAFP00000012949 | ENSLAFP00000002234 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | BRCA2 DNA repair associated. | 0.532 |
| ATR | MCPH1 | ENSLAFP00000012949 | ENSLAFP00000003288 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | BRCT domain-containing protein. | 0.769 |
| ATR | RAD51 | ENSLAFP00000012949 | ENSLAFP00000007349 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.920 |
| ATR | WRN | ENSLAFP00000012949 | ENSLAFP00000003703 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | WRN RecQ like helicase. | 0.975 |
| BRCA2 | ATM | ENSLAFP00000002234 | ENSLAFP00000006871 | BRCA2 DNA repair associated. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.982 |
| BRCA2 | ATR | ENSLAFP00000002234 | ENSLAFP00000012949 | BRCA2 DNA repair associated. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.532 |
| BRCA2 | MCPH1 | ENSLAFP00000002234 | ENSLAFP00000003288 | BRCA2 DNA repair associated. | BRCT domain-containing protein. | 0.828 |
| BRCA2 | RAD51 | ENSLAFP00000002234 | ENSLAFP00000007349 | BRCA2 DNA repair associated. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.999 |
| BRCA2 | WRN | ENSLAFP00000002234 | ENSLAFP00000003703 | BRCA2 DNA repair associated. | WRN RecQ like helicase. | 0.939 |
| CENPJ | MCPH1 | ENSLAFP00000006485 | ENSLAFP00000003288 | Centromere protein J. | BRCT domain-containing protein. | 0.793 |
| CENPJ | STIL | ENSLAFP00000006485 | ENSLAFP00000005246 | Centromere protein J. | STIL centriolar assembly protein. | 0.985 |
| CENPJ | WDR62 | ENSLAFP00000006485 | ENSLAFP00000011485 | Centromere protein J. | WD repeat domain 62. | 0.853 |
| E2F1 | ATM | ENSLAFP00000015179 | ENSLAFP00000006871 | E2F transcription factor 1. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.653 |
