Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PPA1Pyrophosphatase (inorganic) 1. (293 aa)    
Predicted Functional Partners:
ATP5PO
Uncharacterized protein.
  
 
 0.941
ATP5F1C
ATP synthase subunit gamma.
  
 
 0.935
ATP5F1A
ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 
 0.930
LHPP
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase.
   
 
 0.920
MT-ATP6
ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]
  
 
 0.918
ATP5MC1
ATP synthase membrane subunit c locus 1; Belongs to the ATPase C chain family.
   
 
 0.907
ATP6V0C
V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
   
 
 0.907
ATP6V0B
ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.
   
 
 0.907
ATP5MC2
ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family.
   
 
 0.907
ATP6V1A
ATPase H+ transporting V1 subunit A.
   
 
 0.906
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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