SPI1 protein (Loxodonta africana) - STRING interaction network

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Score

SPI1

Spi-1 proto-oncogene. (270 aa)

Predicted Functional Partners:

CSF1R

0.906

FLT3

0.869

RUNX1

0.842

RUNX1T1

0.822

GATA2

0.822

SRF

0.820

PML

0.812

ITGAM

0.811

RARA

0.780

TAL1

0.763

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF1R	ITGAM	ENSLAFP00000014093	ENSLAFP00000011504	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	0.422
CSF1R	RUNX1	ENSLAFP00000014093	ENSLAFP00000003579	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.850
CSF1R	SPI1	ENSLAFP00000014093	ENSLAFP00000003391	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Spi-1 proto-oncogene.	0.906
FLT3	GATA2	ENSLAFP00000013080	ENSLAFP00000022312	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	GATA binding protein 2.	0.407
FLT3	RUNX1T1	ENSLAFP00000013080	ENSLAFP00000004843	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	RUNX1 partner transcriptional co-repressor 1.	0.468
FLT3	SPI1	ENSLAFP00000013080	ENSLAFP00000003391	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Spi-1 proto-oncogene.	0.869
GATA2	FLT3	ENSLAFP00000022312	ENSLAFP00000013080	GATA binding protein 2.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.407
GATA2	RUNX1	ENSLAFP00000022312	ENSLAFP00000003579	GATA binding protein 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.692
GATA2	SPI1	ENSLAFP00000022312	ENSLAFP00000003391	GATA binding protein 2.	Spi-1 proto-oncogene.	0.822
GATA2	SRF	ENSLAFP00000022312	ENSLAFP00000008610	GATA binding protein 2.	Serum response factor.	0.659
GATA2	TAL1	ENSLAFP00000022312	ENSLAFP00000011620	GATA binding protein 2.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.959
ITGAM	CSF1R	ENSLAFP00000011504	ENSLAFP00000014093	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.422
ITGAM	SPI1	ENSLAFP00000011504	ENSLAFP00000003391	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	Spi-1 proto-oncogene.	0.811
PML	RARA	ENSLAFP00000002273	ENSLAFP00000013626	Promyelocytic leukemia.	Retinoic acid receptor alpha.	0.946
PML	RUNX1	ENSLAFP00000002273	ENSLAFP00000003579	Promyelocytic leukemia.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.740
PML	SPI1	ENSLAFP00000002273	ENSLAFP00000003391	Promyelocytic leukemia.	Spi-1 proto-oncogene.	0.812
RARA	PML	ENSLAFP00000013626	ENSLAFP00000002273	Retinoic acid receptor alpha.	Promyelocytic leukemia.	0.946
RARA	SPI1	ENSLAFP00000013626	ENSLAFP00000003391	Retinoic acid receptor alpha.	Spi-1 proto-oncogene.	0.780
RUNX1	CSF1R	ENSLAFP00000003579	ENSLAFP00000014093	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.850
RUNX1	GATA2	ENSLAFP00000003579	ENSLAFP00000022312	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	GATA binding protein 2.	0.692

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