STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLXNB2Sema domain-containing protein. (615 aa)    
Predicted Functional Partners:
SEMA4D
Sema domain-containing protein; Belongs to the semaphorin family.
    
 0.976
RND1
Rho family GTPase 1.
    
 0.968
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
0.961
SEMA4C
Semaphorin 4C; Belongs to the semaphorin family.
    
 0.957
ARHGEF12
Rho guanine nucleotide exchange factor 12.
    
 0.950
SEMA4A
Semaphorin 4A; Belongs to the semaphorin family.
    
 0.936
RRAS
RAS related.
    
 0.933
SEMA4F
Ssemaphorin 4F; Belongs to the semaphorin family.
    
 0.928
G3SX85_LOXAF
Sema domain-containing protein; Belongs to the semaphorin family.
    
 0.922
PLXNB3
Plexin B3.
   
 
0.919
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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