STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLXNB2Sema domain-containing protein. (615 aa)    
Predicted Functional Partners:
ARHGEF11
Rho guanine nucleotide exchange factor 11.
    
 0.934
SEMA4D
Sema domain-containing protein; Belongs to the semaphorin family.
    
 0.909
RHOD
Ras homolog family member D.
    
 0.890
ARHGEF12
Rho guanine nucleotide exchange factor 12.
    
 0.763
SEMA4C
Semaphorin 4C; Belongs to the semaphorin family.
   
0.760
RND1
Rho family GTPase 1.
    
 0.742
RND3
Rho family GTPase 3.
    
 0.684
SEMA4A
Semaphorin 4A; Belongs to the semaphorin family.
    
0.659
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
0.626
G3SX85_LOXAF
Sema domain-containing protein; Belongs to the semaphorin family.
   
 0.622
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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