Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MACC1MET transcriptional regulator MACC1. (737 aa)    
Predicted Functional Partners:
RRS1
Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.
      
 0.817
DNMBP
Dynamin binding protein.
      
 0.807
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 
 0.565
SIX6
SIX homeobox 6.
      
 0.536
PAXIP1
PAX interacting protein 1.
      
 0.494
MDC1
Mediator of DNA damage checkpoint 1.
      
 0.494
ITGA6
Integrin subunit alpha 6; Belongs to the integrin alpha chain family.
   
    0.465
EPS15
Epidermal growth factor receptor pathway substrate 15.
   
 
 0.454
DTYMK
Deoxythymidylate kinase.
      
 0.422
NXPH1
Neurexophilin; May be signaling molecules that resemble neuropeptides.
  
    0.421
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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