STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADNPActivity dependent neuroprotector homeobox. (1101 aa)    
Predicted Functional Partners:
CHD4
Uncharacterized protein.
   
 
 0.811
TRIP12
Thyroid hormone receptor interactor 12.
   
  
 0.757
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
   
 
 0.657
BPTF
Bromodomain PHD finger transcription factor.
   
  
 0.584
ASH1L
ASH1 like histone lysine methyltransferase.
   
 
 0.521
CHD3
Chromodomain helicase DNA binding protein 3.
   
 
 0.489
CHD5
Chromodomain helicase DNA binding protein 5.
   
 
 0.489
CBX3
Uncharacterized protein.
    
 
 0.485
G3TSC5_LOXAF
Uncharacterized protein.
    
 
 0.485
CCL5
SCY domain-containing protein.
  
     0.458
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.