STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)    
Predicted Functional Partners:
SCN8A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
   
 
 0.594
FGF21
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.551
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    
 0.548
FGF18
Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family.
      
 0.531
FGFR1
Fibroblast growth factor receptor.
    
 0.516
BFSP2
Beaded filament structural protein 2; Belongs to the intermediate filament family.
    
 0.500
RGCC
Regulator of cell cycle.
      
 0.489
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
      
 0.481
IL1A
Interleukin-1; Belongs to the IL-1 family.
      
 0.467
FGFR2
Fibroblast growth factor receptor.
    
 0.463
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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