TMEM175 protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TMEM175

Transmembrane protein 175. (500 aa)

Predicted Functional Partners:

LAMP1

0.781

ATP13A2

0.685

DGKQ

0.645

TVP23A

0.642

ATP6V0A1

0.584

GBA

0.549

TMEM17

0.529

PCGF3

0.508

TMEM230

0.502

SLC17A5

0.501

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP13A2	GBA	ENSLAFP00000026862	ENSLAFP00000000188	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Glucosylceramidase.	0.625
ATP13A2	TMEM175	ENSLAFP00000026862	ENSLAFP00000003474	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Transmembrane protein 175.	0.685
ATP6V0A1	GBA	ENSLAFP00000008900	ENSLAFP00000000188	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Glucosylceramidase.	0.400
ATP6V0A1	SLC17A5	ENSLAFP00000008900	ENSLAFP00000007177	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Solute carrier family 17 member 5.	0.510
ATP6V0A1	TMEM175	ENSLAFP00000008900	ENSLAFP00000003474	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Transmembrane protein 175.	0.584
DGKQ	GBA	ENSLAFP00000003477	ENSLAFP00000000188	Diacylglycerol kinase.	Glucosylceramidase.	0.435
DGKQ	PCGF3	ENSLAFP00000003477	ENSLAFP00000003260	Diacylglycerol kinase.	Polycomb group ring finger 3.	0.486
DGKQ	TMEM175	ENSLAFP00000003477	ENSLAFP00000003474	Diacylglycerol kinase.	Transmembrane protein 175.	0.645
GBA	ATP13A2	ENSLAFP00000000188	ENSLAFP00000026862	Glucosylceramidase.	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	0.625
GBA	ATP6V0A1	ENSLAFP00000000188	ENSLAFP00000008900	Glucosylceramidase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.400
GBA	DGKQ	ENSLAFP00000000188	ENSLAFP00000003477	Glucosylceramidase.	Diacylglycerol kinase.	0.435
GBA	LAMP1	ENSLAFP00000000188	ENSLAFP00000009318	Glucosylceramidase.	Lysosomal associated membrane protein 1.	0.582
GBA	TMEM175	ENSLAFP00000000188	ENSLAFP00000003474	Glucosylceramidase.	Transmembrane protein 175.	0.549
LAMP1	GBA	ENSLAFP00000009318	ENSLAFP00000000188	Lysosomal associated membrane protein 1.	Glucosylceramidase.	0.582
LAMP1	SLC17A5	ENSLAFP00000009318	ENSLAFP00000007177	Lysosomal associated membrane protein 1.	Solute carrier family 17 member 5.	0.419
LAMP1	TMEM175	ENSLAFP00000009318	ENSLAFP00000003474	Lysosomal associated membrane protein 1.	Transmembrane protein 175.	0.781
PCGF3	DGKQ	ENSLAFP00000003260	ENSLAFP00000003477	Polycomb group ring finger 3.	Diacylglycerol kinase.	0.486
PCGF3	TMEM175	ENSLAFP00000003260	ENSLAFP00000003474	Polycomb group ring finger 3.	Transmembrane protein 175.	0.508
SLC17A5	ATP6V0A1	ENSLAFP00000007177	ENSLAFP00000008900	Solute carrier family 17 member 5.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.510
SLC17A5	LAMP1	ENSLAFP00000007177	ENSLAFP00000009318	Solute carrier family 17 member 5.	Lysosomal associated membrane protein 1.	0.419

page 1 of 2

Server load: medium (54%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2026

Credits

Access

Info

About