FKBP11 protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FKBP11

Peptidylprolyl isomerase. (198 aa)

Predicted Functional Partners:

CD9

0.542

LOC100674165

0.444

PTGES3

0.441

HYOU1

0.440

HSPA5

0.435

RYR2

0.423

RYR1

0.423

RYR3

0.423

HSP90B1

0.417

PPIB

0.417

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD9	FKBP11	ENSLAFP00000029482	ENSLAFP00000003503	Tetraspanin.	Peptidylprolyl isomerase.	0.542
FKBP11	CD9	ENSLAFP00000003503	ENSLAFP00000029482	Peptidylprolyl isomerase.	Tetraspanin.	0.542
FKBP11	HSP90B1	ENSLAFP00000003503	ENSLAFP00000013455	Peptidylprolyl isomerase.	Heat shock protein 90 beta family member 1.	0.417
FKBP11	HSPA5	ENSLAFP00000003503	ENSLAFP00000008418	Peptidylprolyl isomerase.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.435
FKBP11	HYOU1	ENSLAFP00000003503	ENSLAFP00000015566	Peptidylprolyl isomerase.	Hypoxia up-regulated 1.	0.440
FKBP11	LOC100674165	ENSLAFP00000003503	ENSLAFP00000002518	Peptidylprolyl isomerase.	Uncharacterized protein.	0.444
FKBP11	PPIB	ENSLAFP00000003503	ENSLAFP00000015672	Peptidylprolyl isomerase.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.417
FKBP11	PTGES3	ENSLAFP00000003503	ENSLAFP00000006933	Peptidylprolyl isomerase.	CS domain-containing protein.	0.441
FKBP11	RYR1	ENSLAFP00000003503	ENSLAFP00000026759	Peptidylprolyl isomerase.	Ryanodine receptor 1.	0.423
FKBP11	RYR2	ENSLAFP00000003503	ENSLAFP00000005517	Peptidylprolyl isomerase.	Ryanodine receptor 2.	0.423
FKBP11	RYR3	ENSLAFP00000003503	ENSLAFP00000028747	Peptidylprolyl isomerase.	Ryanodine receptor 3.	0.423
HSP90B1	FKBP11	ENSLAFP00000013455	ENSLAFP00000003503	Heat shock protein 90 beta family member 1.	Peptidylprolyl isomerase.	0.417
HSP90B1	HSPA5	ENSLAFP00000013455	ENSLAFP00000008418	Heat shock protein 90 beta family member 1.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.991
HSP90B1	HYOU1	ENSLAFP00000013455	ENSLAFP00000015566	Heat shock protein 90 beta family member 1.	Hypoxia up-regulated 1.	0.940
HSP90B1	LOC100674165	ENSLAFP00000013455	ENSLAFP00000002518	Heat shock protein 90 beta family member 1.	Uncharacterized protein.	0.793
HSP90B1	PPIB	ENSLAFP00000013455	ENSLAFP00000015672	Heat shock protein 90 beta family member 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.782
HSP90B1	PTGES3	ENSLAFP00000013455	ENSLAFP00000006933	Heat shock protein 90 beta family member 1.	CS domain-containing protein.	0.797
HSPA5	FKBP11	ENSLAFP00000008418	ENSLAFP00000003503	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Peptidylprolyl isomerase.	0.435
HSPA5	HSP90B1	ENSLAFP00000008418	ENSLAFP00000013455	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Heat shock protein 90 beta family member 1.	0.991
HSPA5	HYOU1	ENSLAFP00000008418	ENSLAFP00000015566	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Hypoxia up-regulated 1.	0.994

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

8.16e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 15

2.3

5.28

6.31e-12

GO:0046417

Chorismate metabolic process

4 of 6

2.46

3.07

1.32e-06

GO:0009423

Chorismate biosynthetic process

3 of 5

2.41

2.27

5.21e-05

GO:0009095

Aromatic amino acid family biosynthetic process, prephenate pathway

2 of 2

2.63

1.51

0.0017

GO:0008652

Cellular amino acid biosynthetic process

5 of 108

1.3

1.27

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

3 of 6

2.33

1.74

0.00054

GO:0003856

3-dehydroquinate synthase activity

2 of 2

2.63

1.26

0.0051

GO:0016835

Carbon-oxygen lyase activity

4 of 52

1.52

1.2

0.0019

GO:0016829

Lyase activity

5 of 130

1.22

0.99

0.0019

GO:0003824

Catalytic activity

11 of 2283

0.32

0.24

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1157

Aromatic amino acid family biosynthetic process, and Anthranilate synthase component I-like

9 of 19

2.31

7.07

1.22e-16

CL:1159

Chorismate biosynthetic process

4 of 6

2.46

3.31

4.40e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

zga00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 23

2.27

8.0

6.95e-20

zga01230

Biosynthesis of amino acids

10 of 125

1.54

3.22

1.45e-13

zga01110

Biosynthesis of secondary metabolites

11 of 326

1.16

1.77

7.18e-12

zga01100

Metabolic pathways

11 of 716

0.82

0.89

2.77e-08

zga02024

Quorum sensing

2 of 26

1.52

0.69

0.0386

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 1110

0.54

0.36

0.0243

GOCC:0005622

Intracellular

10 of 1523

0.45

0.31

0.0243

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

3 of 11

2.07

1.76

0.00034

KW-0456

Lyase

6 of 116

1.35

1.54

2.15e-05

KW-0170

Cobalt

2 of 4

2.33

1.25

0.0049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00425

Chorismate binding enzyme

2 of 3

2.46

0.82

0.0315

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030963

3-dehydroquinate synthase family

2 of 2

2.63

0.74

0.0466

IPR030960

3-dehydroquinate synthase domain

2 of 2

2.63

0.74

0.0466

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 3

2.46

0.73

0.0466

IPR005801

ADC synthase

2 of 3

2.46

0.73

0.0466

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About