STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (334 aa)    
Predicted Functional Partners:
SMC5
SMC_N domain-containing protein.
   
 0.975
NSMCE1
NSE1 homolog, SMC5-SMC6 complex component.
   
 0.973
SMC6
Structural maintenance of chromosomes 6.
   
 0.972
NSMCE2
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.
    
 0.970
NSMCE3
NSE3 homolog, SMC5-SMC6 complex component.
   
 0.809
SMC3
Structural maintenance of chromosomes protein.
   
 0.803
SMC4
Structural maintenance of chromosomes protein.
   
 0.730
SMC1B
Structural maintenance of chromosomes protein.
   
 0.728
SMC1A
Structural maintenance of chromosomes protein.
   
 0.728
NDN
Necdin, MAGE family member.
   
 0.714
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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