| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTC1 | POLA1 | ENSLAFP00000025788 | ENSLAFP00000001484 | CST telomere replication complex component 1. | DNA polymerase. | 0.917 |
| CTC1 | POT1 | ENSLAFP00000025788 | ENSLAFP00000004857 | CST telomere replication complex component 1. | Protection of telomeres 1. | 0.977 |
| CTC1 | STN1 | ENSLAFP00000025788 | ENSLAFP00000003528 | CST telomere replication complex component 1. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.998 |
| CTC1 | TEN1 | ENSLAFP00000025788 | ENSLAFP00000015746 | CST telomere replication complex component 1. | Uncharacterized protein. | 0.999 |
| MED1 | MED23 | ENSLAFP00000000953 | ENSLAFP00000003243 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator complex subunit 23. | 0.997 |
| MED1 | MED25 | ENSLAFP00000000953 | ENSLAFP00000022797 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator complex subunit 25. | 0.994 |
| MED1 | MED27 | ENSLAFP00000000953 | ENSLAFP00000009656 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator complex subunit 27. | 0.998 |
| MED1 | MED30 | ENSLAFP00000000953 | ENSLAFP00000002133 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator complex subunit 30. | 0.997 |
| MED1 | MED4 | ENSLAFP00000000953 | ENSLAFP00000000290 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.997 |
| MED1 | STN1 | ENSLAFP00000000953 | ENSLAFP00000003528 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.929 |
| MED23 | MED1 | ENSLAFP00000003243 | ENSLAFP00000000953 | Mediator complex subunit 23. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.997 |
| MED23 | MED25 | ENSLAFP00000003243 | ENSLAFP00000022797 | Mediator complex subunit 23. | Mediator complex subunit 25. | 0.991 |
| MED23 | MED27 | ENSLAFP00000003243 | ENSLAFP00000009656 | Mediator complex subunit 23. | Mediator complex subunit 27. | 0.996 |
| MED23 | MED30 | ENSLAFP00000003243 | ENSLAFP00000002133 | Mediator complex subunit 23. | Mediator complex subunit 30. | 0.992 |
| MED23 | MED4 | ENSLAFP00000003243 | ENSLAFP00000000290 | Mediator complex subunit 23. | Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.998 |
| MED23 | STN1 | ENSLAFP00000003243 | ENSLAFP00000003528 | Mediator complex subunit 23. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.927 |
| MED25 | MED1 | ENSLAFP00000022797 | ENSLAFP00000000953 | Mediator complex subunit 25. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.994 |
| MED25 | MED23 | ENSLAFP00000022797 | ENSLAFP00000003243 | Mediator complex subunit 25. | Mediator complex subunit 23. | 0.991 |
| MED25 | MED27 | ENSLAFP00000022797 | ENSLAFP00000009656 | Mediator complex subunit 25. | Mediator complex subunit 27. | 0.943 |
| MED25 | MED30 | ENSLAFP00000022797 | ENSLAFP00000002133 | Mediator complex subunit 25. | Mediator complex subunit 30. | 0.953 |
