STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD274CD274 molecule. (290 aa)    
Predicted Functional Partners:
PDCD1
Programmed cell death 1.
   
 0.985
G3UII3_LOXAF
Uncharacterized protein.
   
 0.765
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
 
 0.738
CD4
CD4 molecule.
     
 0.709
CD86
Ig-like domain-containing protein.
   
  
 0.673
ICOS
Inducible T cell costimulator.
   
  
 0.672
HAVCR2
Hepatitis A virus cellular receptor 2.
     
 0.594
CD3E
CD3e molecule.
   
 
 0.576
CD8A
CD8a molecule.
   
  
 0.559
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.542
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.