TERF1 protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TERF1

Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)

Predicted Functional Partners:

TINF2

0.998

POT1

0.997

ACD

0.997

TERF2IP

0.996

TNKS

0.980

TNKS2

0.967

FBXO4

0.944

TERB1

0.908

ATM

0.881

DCLRE1B

0.872

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	POT1	ENSLAFP00000005983	ENSLAFP00000004857	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres 1.	0.998
ACD	TERF1	ENSLAFP00000005983	ENSLAFP00000003592	ACD shelterin complex subunit and telomerase recruitment factor.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.997
ACD	TERF2IP	ENSLAFP00000005983	ENSLAFP00000026124	ACD shelterin complex subunit and telomerase recruitment factor.	TERF2 interacting protein.	0.997
ACD	TINF2	ENSLAFP00000005983	ENSLAFP00000011571	ACD shelterin complex subunit and telomerase recruitment factor.	TERF1 interacting nuclear factor 2.	0.999
ACD	TNKS	ENSLAFP00000005983	ENSLAFP00000004005	ACD shelterin complex subunit and telomerase recruitment factor.	Poly [ADP-ribose] polymerase.	0.432
ATM	DCLRE1B	ENSLAFP00000006871	ENSLAFP00000006755	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA cross-link repair 1B.	0.521
ATM	POT1	ENSLAFP00000006871	ENSLAFP00000004857	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protection of telomeres 1.	0.452
ATM	TERF1	ENSLAFP00000006871	ENSLAFP00000003592	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.881
ATM	TINF2	ENSLAFP00000006871	ENSLAFP00000011571	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TERF1 interacting nuclear factor 2.	0.510
DCLRE1B	ATM	ENSLAFP00000006755	ENSLAFP00000006871	DNA cross-link repair 1B.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.521
DCLRE1B	POT1	ENSLAFP00000006755	ENSLAFP00000004857	DNA cross-link repair 1B.	Protection of telomeres 1.	0.826
DCLRE1B	TERF1	ENSLAFP00000006755	ENSLAFP00000003592	DNA cross-link repair 1B.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.872
DCLRE1B	TERF2IP	ENSLAFP00000006755	ENSLAFP00000026124	DNA cross-link repair 1B.	TERF2 interacting protein.	0.960
DCLRE1B	TINF2	ENSLAFP00000006755	ENSLAFP00000011571	DNA cross-link repair 1B.	TERF1 interacting nuclear factor 2.	0.843
FBXO4	TERF1	ENSLAFP00000000128	ENSLAFP00000003592	F-box protein 4.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.944
POT1	ACD	ENSLAFP00000004857	ENSLAFP00000005983	Protection of telomeres 1.	ACD shelterin complex subunit and telomerase recruitment factor.	0.998
POT1	ATM	ENSLAFP00000004857	ENSLAFP00000006871	Protection of telomeres 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.452
POT1	DCLRE1B	ENSLAFP00000004857	ENSLAFP00000006755	Protection of telomeres 1.	DNA cross-link repair 1B.	0.826
POT1	TERB1	ENSLAFP00000004857	ENSLAFP00000007601	Protection of telomeres 1.	Telomere repeat binding bouquet formation protein 1.	0.403
POT1	TERF1	ENSLAFP00000004857	ENSLAFP00000003592	Protection of telomeres 1.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.997

page 1 of 3

Server load: medium (44%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About