STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (957 aa)    
Predicted Functional Partners:
MACROH2A1
Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.
    
 0.896
MACROH2A2
Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.
    
 0.896
HDAC2
Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
  
0.873
CTNNB1
Catenin beta 1.
   
 0.872
MEF2A
Myocyte enhancer factor 2A.
   
 
 0.862
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
 0.858
H2AZ1
Histone H2A; Belongs to the histone H2A family.
   
 0.858
EGFR
Receptor protein-tyrosine kinase.
    
 
 0.830
MEF2D
Myocyte enhancer factor 2D.
   
 
 0.830
NCOR2
Nuclear receptor corepressor 2.
   
 0.825
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.