Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1144 aa)    
Predicted Functional Partners:
SH3KBP1
SH3 domain containing kinase binding protein 1.
    
 
 0.936
GRB2
Growth factor receptor bound protein 2.
    
 
 0.817
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
    
 
 0.703
FYN
Tyrosine-protein kinase.
   
 0.621
PTK6
Tyrosine-protein kinase.
   
 0.621
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1.
   
 0.606
CDC42
Uncharacterized protein.
   
 0.570
PDE2A
Phosphodiesterase.
   
  
 0.568
CRK
CRK proto-oncogene, adaptor protein.
    
 
 0.539
LRCH3
Leucine rich repeats and calponin homology domain containing 3.
      
 0.499
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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