STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)    
Predicted Functional Partners:
IFNGR2
Interferon gamma receptor 2.
    
 0.998
IFNGR1
Interferon gamma receptor 1.
  
 
 0.998
JAK2
Tyrosine-protein kinase.
   
 
 0.982
JAK1
Tyrosine-protein kinase.
   
 
 0.972
IFNAR1
Interferon alpha and beta receptor subunit 1.
     
 0.952
IFNAR2
Uncharacterized protein.
   
 
 0.949
IL10
Interleukin 10.
   
  
 0.942
PSME1
Proteasome activator subunit 1.
   
 
 0.937
PSME2
Uncharacterized protein.
   
 
 0.919
PSME3
Proteasome activator subunit 3.
   
 
 0.918
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.