STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHM2Pleckstrin homology and RUN domain containing M2. (1047 aa)    
Predicted Functional Partners:
RAB9B
RAB9B, member RAS oncogene family.
     
  0.900
RAB9A
RAB9A, member RAS oncogene family.
     
  0.900
UBB
Ubiquitin B.
   
 
 0.683
UBC
Uncharacterized protein.
   
 
 0.683
RAD23B
RAD23 homolog B, nucleotide excision repair protein.
   
 
 0.661
RAD23A
RAD23 homolog A, nucleotide excision repair protein.
   
 
 0.661
PSMD2
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
    
 
 0.595
PSMD14
Proteasome 26S subunit, non-ATPase 14.
   
 
 0.591
PSMD4
Proteasome 26S subunit, non-ATPase 4.
   
 
 0.574
RPS27A
Ubiquitin-like domain-containing protein.
   
 
 0.555
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.