PRPF31 protein (Loxodonta africana) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

PRPF31

Pre-mRNA processing factor 31. (499 aa)

Predicted Functional Partners:

SNU13

0.998

SART1

0.997

PRPF3

0.997

PRPF4

0.997

PRPF6

0.996

PRPF8

0.996

SNRNP200

0.995

LSM8

0.994

EFTUD2

0.993

MFAP1

0.991

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFTUD2	LSM8	ENSLAFP00000012857	ENSLAFP00000009397	Elongation factor Tu GTP binding domain containing 2.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.991
EFTUD2	MFAP1	ENSLAFP00000012857	ENSLAFP00000006192	Elongation factor Tu GTP binding domain containing 2.	Microfibril associated protein 1.	0.985
EFTUD2	PRPF3	ENSLAFP00000012857	ENSLAFP00000003940	Elongation factor Tu GTP binding domain containing 2.	Pre-mRNA processing factor 3.	0.991
EFTUD2	PRPF31	ENSLAFP00000012857	ENSLAFP00000003804	Elongation factor Tu GTP binding domain containing 2.	Pre-mRNA processing factor 31.	0.993
EFTUD2	PRPF4	ENSLAFP00000012857	ENSLAFP00000015268	Elongation factor Tu GTP binding domain containing 2.	Pre-mRNA processing factor 4.	0.987
EFTUD2	PRPF6	ENSLAFP00000012857	ENSLAFP00000004417	Elongation factor Tu GTP binding domain containing 2.	Pre-mRNA processing factor 6.	0.999
EFTUD2	PRPF8	ENSLAFP00000012857	ENSLAFP00000012947	Elongation factor Tu GTP binding domain containing 2.	Pre-mRNA processing factor 8.	0.999
EFTUD2	SART1	ENSLAFP00000012857	ENSLAFP00000001476	Elongation factor Tu GTP binding domain containing 2.	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	0.995
EFTUD2	SNRNP200	ENSLAFP00000012857	ENSLAFP00000013115	Elongation factor Tu GTP binding domain containing 2.	Small nuclear ribonucleoprotein U5 subunit 200.	0.999
EFTUD2	SNU13	ENSLAFP00000012857	ENSLAFP00000009223	Elongation factor Tu GTP binding domain containing 2.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.984
LSM8	EFTUD2	ENSLAFP00000009397	ENSLAFP00000012857	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Elongation factor Tu GTP binding domain containing 2.	0.991
LSM8	MFAP1	ENSLAFP00000009397	ENSLAFP00000006192	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Microfibril associated protein 1.	0.720
LSM8	PRPF3	ENSLAFP00000009397	ENSLAFP00000003940	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA processing factor 3.	0.993
LSM8	PRPF31	ENSLAFP00000009397	ENSLAFP00000003804	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA processing factor 31.	0.994
LSM8	PRPF4	ENSLAFP00000009397	ENSLAFP00000015268	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA processing factor 4.	0.990
LSM8	PRPF6	ENSLAFP00000009397	ENSLAFP00000004417	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA processing factor 6.	0.989
LSM8	PRPF8	ENSLAFP00000009397	ENSLAFP00000012947	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA processing factor 8.	0.989
LSM8	SART1	ENSLAFP00000009397	ENSLAFP00000001476	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	0.987
LSM8	SNRNP200	ENSLAFP00000009397	ENSLAFP00000013115	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein U5 subunit 200.	0.988
LSM8	SNU13	ENSLAFP00000009397	ENSLAFP00000009223	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.932

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

10

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031204

Post-translational protein targeting to membrane, translocation

4 of 6

3.28

4.69

2.97e-09

GO:0045047

Protein targeting to ER

5 of 28

2.7

4.55

2.49e-09

GO:0006612

Protein targeting to membrane

5 of 51

2.44

4.16

6.70e-09

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

4 of 17

2.82

3.98

4.00e-08

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

3 of 5

3.23

3.36

8.22e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043022

Ribosome binding

4 of 61

2.27

2.52

1.25e-05

GO:0008320

Protein transmembrane transporter activity

2 of 13

2.64

1.13

0.0088

GO:0019838

Growth factor binding

2 of 18

2.5

1.12

0.0088

GO:0042562

Hormone binding

2 of 26

2.34

1.04

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140534

Endoplasmic reticulum protein-containing complex

7 of 74

2.43

6.44

3.60e-14

GO:0071256

Translocon complex

4 of 4

3.45

5.6

7.00e-11

GO:0005789

Endoplasmic reticulum membrane

11 of 581

1.73

4.5

1.14e-16

GO:0005784

Sec61 translocon complex

3 of 3

3.45

4.0

5.84e-08

GO:0008250

Oligosaccharyltransferase complex

3 of 10

2.93

3.38

6.25e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31634

Oligosaccharyltransferase complex, and Post-translational protein targeting to membrane, translocation

10 of 24

3.07

13.33

2.63e-26

CL:31636

Oligosaccharyltransferase complex, and Translocon-associated

8 of 18

3.1

10.68

7.22e-21

CL:31661

Mixed, incl. Sec61beta family, and Translocon-associated

5 of 5

3.45

6.95

2.28e-13

CL:31638

Oligosaccharyltransferase complex

3 of 11

2.89

5.12e-06

CL:31641

Oligosaccharyltransferase complex

2 of 5

3.05

1.68

0.00093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

10 of 303

1.97

5.9

1.62e-17

map03060

Protein export

4 of 39

2.46

3.66

8.41e-08

map04145

Phagosome

4 of 151

1.87

2.29

1.03e-05

map00510

N-Glycan biosynthesis

2 of 71

1.9

0.99

0.0120

map00513

Various types of N-glycan biosynthesis

2 of 80

1.85

0.98

0.0121

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 115

2.17

4.09

1.80e-09

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

3 of 17

2.7

2.59

1.62e-05

MAP-72766

Translation

6 of 322

1.72

2.56

3.76e-07

MAP-9609507

Protein localization

3 of 210

1.61

0.87

0.0163

MAP-392499

Metabolism of proteins

6 of 2399

0.85

0.54

0.0181

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 6

3.37

6.9

2.69e-13

GOCC:0005789

Endoplasmic reticulum membrane

9 of 199

2.11

6.09

7.43e-16

GOCC:0005784

Sec61 translocon complex

4 of 5

3.35

5.38

1.69e-10

GOCC:0005783

Endoplasmic reticulum

10 of 354

1.9

5.24

5.63e-16

GOCC:0098796

Membrane protein complex

8 of 516

1.64

3.15

1.69e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 61

2.27

2.93

1.65e-06

KW-0811

Translocation

2 of 13

2.64

1.72

0.00069

KW-1133

Transmembrane helix

10 of 6441

0.64

0.55

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

2 of 2

3.45

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030671

Protein transport Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

IPR016482

Protein transport protein SecG/Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

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