DYRK3 protein (Loxodonta africana) - STRING interaction network

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DYRK3

Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)

Predicted Functional Partners:

ATM

0.769

DCAF1

0.697

DCAF7

0.602

MDM2

0.597

RPS27A

0.527

G3U9C8_LOXAF

0.527

EEF2

0.498

DDB1

0.493

KATNA1

0.484

SPTSSB

0.483

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DDB1	ENSLAFP00000006871	ENSLAFP00000009624	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Damage specific DNA binding protein 1.	0.465
ATM	DYRK3	ENSLAFP00000006871	ENSLAFP00000003810	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.769
ATM	G3U9C8_LOXAF	ENSLAFP00000006871	ENSLAFP00000024436	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.637
ATM	MDM2	ENSLAFP00000006871	ENSLAFP00000004935	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.992
ATM	RPS27A	ENSLAFP00000006871	ENSLAFP00000021261	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.637
DCAF1	DDB1	ENSLAFP00000010605	ENSLAFP00000009624	DDB1 and CUL4 associated factor 1.	Damage specific DNA binding protein 1.	0.998
DCAF1	DYRK3	ENSLAFP00000010605	ENSLAFP00000003810	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.697
DCAF7	DDB1	ENSLAFP00000008543	ENSLAFP00000009624	DDB1 and CUL4 associated factor 7.	Damage specific DNA binding protein 1.	0.970
DCAF7	DYRK3	ENSLAFP00000008543	ENSLAFP00000003810	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.602
DDB1	ATM	ENSLAFP00000009624	ENSLAFP00000006871	Damage specific DNA binding protein 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.465
DDB1	DCAF1	ENSLAFP00000009624	ENSLAFP00000010605	Damage specific DNA binding protein 1.	DDB1 and CUL4 associated factor 1.	0.998
DDB1	DCAF7	ENSLAFP00000009624	ENSLAFP00000008543	Damage specific DNA binding protein 1.	DDB1 and CUL4 associated factor 7.	0.970
DDB1	DYRK3	ENSLAFP00000009624	ENSLAFP00000003810	Damage specific DNA binding protein 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.493
DDB1	G3U9C8_LOXAF	ENSLAFP00000009624	ENSLAFP00000024436	Damage specific DNA binding protein 1.	Ubiquitin-like domain-containing protein.	0.757
DDB1	MDM2	ENSLAFP00000009624	ENSLAFP00000004935	Damage specific DNA binding protein 1.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.485
DDB1	RPS27A	ENSLAFP00000009624	ENSLAFP00000021261	Damage specific DNA binding protein 1.	Ubiquitin-like domain-containing protein.	0.757
DYRK3	ATM	ENSLAFP00000003810	ENSLAFP00000006871	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.769
DYRK3	DCAF1	ENSLAFP00000003810	ENSLAFP00000010605	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 1.	0.697
DYRK3	DCAF7	ENSLAFP00000003810	ENSLAFP00000008543	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 7.	0.602
DYRK3	DDB1	ENSLAFP00000003810	ENSLAFP00000009624	Dual specificity tyrosine phosphorylation regulated kinase 3.	Damage specific DNA binding protein 1.	0.493

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