STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HUNKHormonally up-regulated Neu-associated kinase. (685 aa)    
Predicted Functional Partners:
APPL2
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.
    
  0.813
APPL1
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.
    
  0.813
CHAF1B
Chromatin assembly factor 1 subunit B.
   
  
 0.794
SCN8A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
      
 0.699
TRAPPC1
Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.
    
   0.677
ZBTB21
Zinc finger and BTB domain containing 21.
    
 0.676
MIS18A
MIS18 kinetochore protein A.
   
  
 0.584
PTPN7
Protein tyrosine phosphatase non-receptor type 7.
   
  
 0.576
BRD2
Bromodomain containing 2.
    
 
 0.573
FNIP2
Folliculin interacting protein 2.
    
 
 0.552
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.