Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RAD18RAD18 E3 ubiquitin protein ligase. (477 aa)    
Predicted Functional Partners:
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.994
POLH
DNA polymerase eta.
    
 
 0.973
SHPRH
SNF2 histone linker PHD RING helicase.
    
 0.958
UBE2B
Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.941
HLTF
Helicase like transcription factor.
   
 0.936
SLF1
ANK_REP_REGION domain-containing protein.
   
 
 0.934
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit.
   
 0.934
UBE2A
Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.932
FANCD2
FA complementation group D2.
   
 
 0.927
UBE2V2
Ubiquitin conjugating enzyme E2 V2.
    
 0.918
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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