STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN12Tetraspanin. (305 aa)    
Predicted Functional Partners:
NDP
Norrin cystine knot growth factor NDP.
    
 0.898
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
   
 
 0.898
LRP5
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
      
 0.584
RECK
Reversion inducing cysteine rich protein with kazal motifs.
      
 0.583
ADGRA2
Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.
      
 0.571
ZNF408
Zinc finger protein 408.
      
 0.571
LGR4
Leucine rich repeat containing G protein-coupled receptor 4.
      
 0.562
TSPAN15
Tetraspanin.
      
 0.533
LGR5
Leucine rich repeat containing G protein-coupled receptor 5.
      
 0.441
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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