Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (354 aa)    
Predicted Functional Partners:
LOC100669226
Uncharacterized protein.
    
  0.871
GNAL
G protein subunit alpha L.
    
 0.850
G3UF61_LOXAF
Uncharacterized protein.
    
 0.850
HRH4
Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family.
    
 0.810
HRH3
Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family.
    
 0.810
HRH1
Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.809
CHRM4
Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
   
 
 0.809
CHRM2
Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
   
 
 0.697
ATP4A
ATPase H+/K+ transporting subunit alpha; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
      
 0.650
OCM2
Uncharacterized protein; Belongs to the parvalbumin family.
     
 0.622
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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