Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTPRBProtein tyrosine phosphatase receptor type B. (1980 aa)    
Predicted Functional Partners:
CDH5
Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.
   
 0.915
ADGRF5
Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.904
CTNNB1
Catenin beta 1.
    
 0.890
TEK
TEK receptor tyrosine kinase.
   
 0.742
INPP1
Inositol polyphosphate-1-phosphatase.
      
 0.664
SLC25A12
Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.652
EGFR
Receptor protein-tyrosine kinase.
    
 0.634
TP73
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
      
 0.622
MFN2
Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
    
 0.600
TBC1D31
TBC1 domain family member 31.
      
 0.594
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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